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Faculty

Steven J. Geary, Interim Department Head

Background

Education

1970-1974 University of Connecticut, B.S
1974-1980 University of Connecticut, Ph.D. in Microbiology
1980-1981 University of Missouri, Post-Doctoral Fellow, Department of Microbiology

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Contact

Department of Pathobiology, U-3089
61 North Eagleville Road
The University of Connecticut
Storrs, Connecticut 06269-3089
Telephone: (860) 486-8098


Fax: (860) 486-2794

Email: Steven.Geary@uconn.edu

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Courses Taught

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Research Interests

  1. Molecular biology of mycoplasmas. Cloning, expression and sequence analysis of genes encoding regulatory and virulence determinants. Modulation of gene expression by regulatory proteins.
  2. Mycoplasma genomics, microarray (expression) analysis, proteomics.
  3. Pathogenic mechanisms of mycoplasmas. Mechanisms of attachment; cytadherence molecules and host cell receptors. Investigation of variably expressed cell surface proteins.
  4. Vaccine Development. Immunologic and genetic means of analysis for the detection and speciation of mycoplasmas.

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Publications

  • Draghi, A., Bebak, J., Popov, V. L., Noble, A.C., Geary, S. J., West, A. B., Byrne, P. and S. Frasca Jr. 2007. “Characterization of a Neochlamydia-like Bacterium Associated with Epithiocystis in Cultured Arctic Char” (Salvelinus alpinus)”. Diseases of Aquatic Organisms vol 76 27-38

    Jenkins, C., Geary, S. J. and S. P. Djordjevic. 2007. “The Mycoplasma gallisepticum OsmC-like protein MG1142 resides on the cell surface and binds heparin” Microbiology 2007 May;153 (Pt 5):1455-63.

    Cecchini , K.R., T.S. Gorton, and S.J. Geary. 2007 “Transcriptional Responses of Mycoplasma gallisepticum Strain R in Association with Eukaryotic Cells” J Bacteriol. 2007 Aug; 189(16):5803-7. Epub 2007 Jun 8.

    Balinsky, C.A., Delhon, G., Alfonso, C. L., Risatti, G. R., Borca, M. V., French, R. A., Tulman, E. R., Geary, S. J. and D. L. Rock. 2007. “Sheeppox Virus Kelch-like Gene SPPV-019 Affects Virus Virulence”. J. Virol. Aug 8.

  • Javed M.A., Frasca, S. Jr., Cecchini K., Rood, D., Nyaoke A.C., Geary, S.J., Silbart, L.K  (2007) “Chemokine and Cytokine Gene Expression Profiles in Chickens Inoculated with Mycoplasma gallisepticum Strains Rlow and GT5”. Vaccine, Oct 16

    Balinsky CA, Delhon G, Smoliga G, Prarat M, French RA, Geary SJ, Rock DL, Rodriguez LL. 2007. “Rapid Preclinical Detection of Sheeppox Virus by a Real-Time PCR Assay”. J Clin Microbiol. Nov 21

    A. Gates, S. Frasca Jr, A. Nyaoke, T.S. Gorton, L.K. Silbart, and S. J. Geary (2007)
    “Comparative Assessment of a Metabolically Attenuated Mycoplasma gallisepticum Mutant as a Live Vaccine for the Prevention of Avian Respiratory Mycoplasmosis”. Vaccine. 2008 Apr 7;26(16):2010-9. Epub 2008 Feb 22.

  • S. M. Szczepanek, S. Frasca Jr. and S. J. Geary (2007) “Global in vitro Transcriptomic Comparison of Mycoplasma gallisepticum Strains Rlow and F”. Conference of Research Workers in Animal Diseases, Chicago, IL, 12/07 
    Note: Steve won best student presentation

    S. M. Szczepanek, Liao, X., Tulman, E., Siddiqui, S., Rood, D., Gladd, M., Wyand S., Silbart L.K. and S. J. Geary (2008) “Generation and Evaluation of an Attenuated Strain of Mycoplasma pneumoniae” The 108th National Meeting of The American Society for Microbiology, Boston, MA, 5/6/2/08

  • Geary, S.J., Gabridge, M.G., Intres, R., Draper, D.L., and M. F. Gladd. 1989. Identification of Mycoplasma binding proteins utilizing a 100 Kilodalton Lung Fibroblast Receptor. J. Receptor Res. 9: 465-478.
  • Forsyth, M.H., Tourtellotte, M.E., and S.J. Geary. 1992. Localization of an immunodominant 64 kDa lipoprotein (LP64) in the membrane of Mycoplasma gallisepticum and its role in cytadherence. Mol. Micro. 6:2099-2106.
  • Gorton, T.S., Goh, M.S., and S.J. Geary. 1995. Physical mapping of the Mycoplasma gallisepticum S6 genome with localization of selected genes. J. Bacteriol. 177:259-263. (Download PDF)
  • Forsyth, M. H., Saoud, S., and S.J. Geary. 1995.Sequence and transcriptional analysis of the genes encoding the class-11 topoisomerase of Mycoplasma gallisepticum. Gene. 163:161-162.
  • Forsyth, M. H. and S. J. Geary. 1996. The repetitive element RepMP1 of Mycoplasma pneumoniae exists as a core element within a larger, variable repetitive mosaic. J. Bacteriol. 178:917-921. (Download PDF)
  • Gorton, T. S. and S. J. Geary. 1997. Antibody mediated selection of Mycoplasma gallisepticum phenotypes expressing variable surface proteins. FEMS Microbiology Letters, 155(1)31-38. (Download PDF)
  • Goh, M. S., Gorton, T. S., Forsyth, M. H, Troy, K. E., and S. J. Geary. 1998. Molecular and biochemical analysis of a 105 kDa Mycoplasma gallisepticum cytadhesin (GapA). Microbiology, 144:2941-2950. (Download PDF)
  • Papazisi, L., K. E. Troy, T. S. Gorton, X. Liao, S. J. Geary. 2000. Analysis of a GapA- Cytadherence Deficient Mycoplasma gallisepticum Strain R Infect Immun 68: 6643-6649. (Download PDF)
  • Papazisi,L., Silbart, L.K., Frasca Jr., S., Rood, D., Liao,X., Gladd, M.Javed, M.A. and Geary, S.J. 2002. A Modified Live Mycoplasma gallisepticum Vaccine to Protect Chickens From Respiratory Disease, Vaccine, 20(31-32), 3709-3719.
  • Papazisi,L., S.Frasca,Jr., M.Gladd, X.Liao, D.Yogev, S.J.Geary. 2002. GapA and CrmA co-expression is essential for Mycoplasma gallisepticum cytadherence and virulence, Infect. Immunity, December 2002.70:6839-45 (Download PDF)
  • The complete genome sequence of Mycoplasma gallisepticum Strain R , GenBank Accession #: AE015450, October 17th, 2002.
  • Papazisi, L., Gorton, T., Kutish, G., Markham, P., Browning, G., Nguyen, D., Swartzell, S., Madan, A., Mahairas, G. and S. J. Geary. 2003. The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain Rlow. Microbiology. 2003 Sep; 149(Pt 9):2307-16
  • Browning, G., Whithear, K., and S. J. Geary. 2004. "Vaccines." In Mycoplasmas: pathogenesis, molecular biology, and emerging strategies for control. Blanchard, A. and G. Browning eds. Horizon Scientific Publishers.

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Links

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